Hiroyuki Kusuhara Selected Research

Member 1 Subfamily B ATP Binding Cassette Transporter

1/2022	Usefulness of Human Jejunal Spheroid-Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans.
1/2021	Characterization of the Human Intestinal Drug Transport with Ussing Chamber System Incorporating Freshly Isolated Human Jejunum.
7/2015	Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.
6/2014	Quantitative investigation of the brain-to-cerebrospinal fluid unbound drug concentration ratio under steady-state conditions in rats using a pharmacokinetic model and scaling factors for active efflux transporters.
9/2013	Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.
12/2011	Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate.
6/2010	Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
2/2008	P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
1/2005	Active efflux across the blood-brain barrier: role of the solute carrier family.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Hiroyuki Kusuhara Research Topics

Disease

36	Breast Neoplasms (Breast Cancer) 01/2022 - 09/2004
9	Neoplasms (Cancer) 01/2021 - 03/2010
7	Cholestasis 04/2024 - 02/2007
5	progressive familial intrahepatic 1 Cholestasis 01/2021 - 05/2014
4	Intrahepatic Cholestasis 12/2021 - 12/2015
4	Infections 05/2014 - 02/2007
3	Inborn Urea Cycle Disorders 12/2021 - 11/2019
3	Hypercholesterolemia 12/2019 - 12/2004
3	Pruritus (Itching) 02/2016 - 05/2014
2	Inflammation (Inflammations) 01/2024 - 10/2021
2	Neoplasm Metastasis (Metastasis) 01/2023 - 12/2013
2	Liver Diseases (Liver Disease) 01/2021 - 06/2016
2	Renal Insufficiency (Renal Failure) 01/2021 - 02/2007
2	Hepatocellular Carcinoma (Hepatoma) 12/2016 - 12/2013
2	Human Influenza (Influenza) 01/2014 - 02/2008
2	Tics (Tic) 05/2012 - 11/2010
2	Muscular Diseases (Myopathy) 12/2010 - 02/2009
2	Cerebral Infarction 11/2007 - 08/2007
2	Type 2 Diabetes Mellitus (MODY) 04/2003 - 08/2002
1	Necrosis 04/2024
1	Hepatitis 01/2024
1	Experimental Arthritis 01/2024
1	Arthritis (Polyarthritis) 01/2024
1	Diarrhea 12/2023
1	Fatty Liver 11/2023
1	Adenocarcinoma of Lung 01/2023
1	Chemical and Drug Induced Liver Injury 10/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2021

Drug/Important Bio-Agent (IBA)

38	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2003
9	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2022 - 01/2005
6	4-phenylbutyric acid (Buphenyl)FDA Link 12/2021 - 05/2014
6	Multidrug Resistance-Associated ProteinsIBA 11/2013 - 01/2007
5	AnionsIBA 01/2020 - 02/2007
5	Peptides (Polypeptides)IBA 01/2020 - 02/2007
4	Bile Acids and Salts (Bile Acids)IBA 04/2024 - 12/2015
4	CholesterolIBA 01/2023 - 12/2013
4	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 06/2016 - 05/2008
4	Messenger RNA (mRNA)IBA 07/2015 - 10/2003
4	ATP-Binding Cassette Transporters (ABC Transporters)IBA 07/2012 - 01/2005
3	Adenosine Triphosphate (ATP)IBA 07/2012 - 01/2007
3	EstersIBA 05/2012 - 02/2008
3	Mitoxantrone (Novantrone)FDA LinkGeneric 06/2010 - 01/2005
3	Excipients (Suspending Agents)IBA 03/2009 - 07/2007
3	XenobioticsIBA 06/2008 - 01/2005
3	Hypoglycemic Agents (Hypoglycemics)IBA 02/2007 - 08/2002
2	Peptide Transporter 1IBA 01/2022 - 01/2021
2	EnzymesIBA 01/2022 - 12/2013
2	Adenosine Triphosphatases (ATPase)IBA 01/2021 - 12/2019
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2021 - 10/2013
2	pitavastatin (itavastatin)FDA Link 10/2019 - 09/2005
2	DiureticsIBA 01/2019 - 08/2017
2	Therapeutic UsesIBA 06/2016 - 05/2014
2	sodium-bile acid cotransporterIBA 05/2014 - 08/2007
2	Oseltamivir (Tamiflu)FDA Link 01/2014 - 02/2008
2	Amino Acid Transport Systems (Amino Acid Transporter)IBA 09/2013 - 01/2012
2	2- amino- 3- (4- ((5- amino- 2- phenylbenzo(d)oxazol- 7- yl)methoxy)- 3,5- dichlorophenyl)propanoic acidIBA 09/2013 - 01/2012
2	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2013 - 07/2012
2	AcidsIBA 05/2012 - 11/2010
2	Pravastatin (Pravachol)FDA LinkGeneric 12/2010 - 02/2009
2	Multidrug Resistance-Associated Protein 2IBA 11/2010 - 07/2005
2	ProdrugsIBA 02/2008 - 04/2005
2	EdaravoneIBA 11/2007 - 08/2007
2	Free Radical ScavengersIBA 11/2007 - 08/2007
2	Sulfates (Sulfates, Inorganic)IBA 11/2007 - 06/2007
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2004 - 10/2004
2	Metformin (Glucophage)FDA LinkGeneric 04/2003 - 08/2002
2	BiguanidesIBA 04/2003 - 08/2002
1	Transaminases (Aminotransferases)IBA 04/2024
1	NF-kappa B (NF-kB)IBA 01/2024
1	factor XIIa inhibitor (INH(1))IBA 01/2024
1	LipopolysaccharidesIBA 01/2024
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2024
1	GalactosamineIBA 01/2024
1	pyrimidineIBA 01/2024
1	Collagen Type II (Type II Collagen)IBA 01/2024
1	AminesIBA 01/2024
1	Tyrosine Kinase InhibitorsIBA 12/2023
1	AfatinibIBA 12/2023
1	ErbB Receptors (EGF Receptor)IBA 12/2023
1	osimertinibIBA 12/2023
1	Choline (Choline Chloride)IBA 11/2023
1	Untranslated RNA (Noncoding RNA)IBA 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	OligonucleotidesIBA 01/2023
1	RNA (Ribonucleic Acid)IBA 01/2023
1	glutathione S-transferase M1IBA 10/2022
1	Glutathione Transferase (Glutathione S-Transferase)IBA 10/2022
1	UridineIBA 01/2022
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2022
1	Cytochrome P-450 CYP2C9IBA 01/2022
1	Carboxylesterase (Hydrolase S)IBA 01/2022
1	angiotensin I (1-7)IBA 10/2021
1	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 10/2021
1	Ribavirin (Virazole)FDA LinkGeneric 01/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021
1	Methotrexate (Mexate)FDA LinkGeneric 01/2021
1	Cefadroxil (Duricef)FDA LinkGeneric 01/2021
1	NucleosidesIBA 01/2021

Therapy/Procedure

6	Therapeutics 11/2023 - 01/2014
1	Oral Administration 12/2021